Endocrine Abstracts

Background: Survival of patients after the transplantation (Tx) of solid organs is improving. Osteoporosis and bone fractures belong to their long-term complications. The contributing factors are disturbances of bone metabolism in pre-transplant period and immunosuppressive therapy including corticosteroids after the transplantation.Patients and methods: We investigated the prevalence of osteoporosis and osteopenia in 248 diabetic patients after the Tx o...

Introduction: Organ transplant recipients are at increased fracture risk compared to general population. Bone mineral density (BMD), predictive of fracture in general population, does not reflect impaired bone quality frequently present in patients with advanced organ failure. Trabecular bone score (TBS) provides surrogate measures of bone microarchitecture and therefore helps to identify persons at risk for fracture among transplant recipients.Methods: ...

Objective: Osteoporosis is a typical long-term complication after solid organ transplantation. Patients after simultaneous pancreas kidney transplantation (SPK) are at a very high risk due to preceding renal osteopathy and diabetic status. To determine the best preventive strategy we analysed the bone metabolism at the point of the pretransplant examination.Design and methods: In years 2011–2014 the number of 112 patients with type 1 diabetes (69 me...

Introduction: The transplantation- associated osteoporosis became an increasingly important problem with the better survival of patients after the solid organ transplantation (Tx). Adequate vitamin D intake, calcium supplementation and bisphosphonates therapy are currently recommended for osteoporosis treatment. However bisphosphonates may be limited with patients’ impaired renal function. Denosumab use is the possible option but till now only a little data exist in solid...

Background: Organ transplantation (Tx) is the standard treatment for end-stage renal failure in diabetic patients. With an improvement in patient and graft survival, the bone loss and persistent abnormalities in bone metabolism are long-term complications to manage.Patients and methods: We investigated the prevalence of osteoporosis and osteopenia in 256 diabetic patients (142M, 114F) after the kidney and pancreas Tx for renal failure due to diabetic nep...

Adrenal incidentaloma is frequently encountered in endocrinological praxis, however in specific situations the proper investigation is almost impossible. A 60-years old patient was admitted to our intensive care unit with a myocardial infarction in cardiogenic shock requiring ionotropic support and intraaortic balloon counterpulsation. On account of ejection fraction 15–20% an urgent pretransplantation investigation was started. Abdominal ultrasound displayed a hypoechoge...